Post Doctoral Fellow (NCI)
The Basic Science Program (BSP) pursues independent, multidisciplinary research programs in basic or applied molecular biology, immunology, retrovirology, cancer biology or human genetics. Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR). The major focus of the Hematopoiesis & Stem Cell Biology Section of the BSP is to identify and define the cellular and molecular pathways that regulate normal HSC development. The lab is currently focused on understanding how transcription factors regulate HSC quiescence, survival, self-renewal, and cell fate, and how they are integrated into wider transcription factor regulatory networks that regulate HSC. Increasing the understanding of the molecular and cellular regulation of hematopoiesis will contribute to 1) an improved understanding of stem cell quiescence, self-renewal, and cell fate, 2) improved methods to expand and transplant HSCs for regenerative medicine and gene therapy, 3) enhancing our understanding of the leukemogenic process, and discovery of novel therapies to treat hematopoietic malignancies. The laboratories areas of expertise include: stem cell biology, hematopoiesis, transcription factors, hematopoietic malignancies, molecular regulation of self renewal and cell fate, and bone marrow transplantation.
This position description does not represent a current opening but may be used to identify candidates with skills and experience for positions within Leidos Biomedical Research that frequently become available. Candidates who express an interest may be considered for future positions at Leidos Biomedical Research.
A postdoctoral position is needed to participate in projects focusing on the molecular and cellular regulation of hematopoietic stem/progenitor cell quiescence, self-renewal and differentiation. Particular emphasis is placed on defining the function of transcription factors, and transcriptional regulators in these processes in vivo. These studies include defining the mechanism(s) of how these transcription factors integrate into larger transcription factor networks to regulate target gene expression and pathways that regulate normal and malignant stem cell development. Efforts are also focused on defining the role of the hematopoietic microenvironment in stem cell maintenance and differentiation. Methods include the use of and development of novel transgenic and conditional mutant mouse models to study gene function and mechanism(s) of action in stem cell biology. The laboratory environment, resources and support on the Frederick-NCI campus are outstanding.
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a Doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation.
- Foreign degrees must be evaluated for U.S. equivalency
- No experience required beyond the education requirements
- Must be able to obtain and maintain a security clearance
Candidates with these desired skills will be given preferential consideration:
- Knowledge and experience in stem cell biology, molecular biology and biochemistry
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