Electron Microscopist/Structural Biologist (NCI)
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR). The dedicated units provide electron microscopy, protein characterization, protein expression, optical microscopy and genetics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR). CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.
KEY ROLES/RESPONSIBILITIES-THIS POSITION IS CONTINGENT UPON FUNDING APPROVAL
Electron Microscopist/Structural Biologist
- Provide technical advice to investigators on sample preparation, and data collection
- Operate TEM microscopes, specifically Titan Krios and Talos Artctica; task will include loading samples, screening, and performing high-resolution data collection for single particle studies as well as cryo-electron tomography
- Manage maintenance for the Titan Krios and the Talos Arctica as well as associated instruments (T20)
- Train new CMM employees and other users in the use of the Krios and data collection software as well as in the sample preparation techniques
- Interact closely with colleagues within the CMM
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a Doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation in Biological Sciences, Structural Biology, or related discipline (Additional qualifying experience may be substituted for the required education)
- Foreign degrees must be evaluated for U.S. equivalency
- In addition to the education requirements, a minimum of two (2) years of experience with Cryo-EM, Cryo-electron tomography, and high resolution single-particle analysis
- Must be detail-oriented and able to manage multiple projects simultaneously
- Able to prepare detailed, concise technical reports
- Strong laboratory skills
- Must be able to obtain and maintain a security clearance
Candidates with these desired skills will be given preferential consideration:
- Five years of experience
- Experience with negative stain and other specimen preparation techniques for EM.
- Experience with the microED technology is a plus
- Use of TEM microscopes, Titan Krios, Talos Arctica, T20.
- Manage sample preparation for cryo-EM studies as well as for negative stain screening.
- Maintenance of TEM microscopes
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