The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers.
- The Cancer Research Technology Program (CRTP) within the Frederick National Laboratory for Cancer Research (FNLCR) serves as the hub for the NCI RAS Initiative. One of the major objectives of the structural biology group within the RAS initiative is to solve structures of RAS in complex with lead compounds in support of various drug discovery projects.
- The candidate will join the structural biology group and be responsible for carrying out crystallization and structural studies on KRAS-small molecule complexes and play a key role in structure-based drug design projects.
- The candidate will be expected to be able to participate in project-based and technical team meetings to identify and solve problems, and plan forward thinking strategies.
- Rigorous and detail-oriented experimentalist with a desire to continue in a laboratory-focused role.
- The candidate will be responsible for completing projects independently and as part of a team, and will be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing.
- Work may involve the use of potentially hazardous chemical, biological, or radiological materials or may be located in areas where such materials are used.
- Work will require the use of personal protective equipment and adherence to strict safety protocols.
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a PhD degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in Structural Biology, Computational Chemistry, Biophysics, or related field. (Additional qualifying experience may be substituted for the required education).
- Foreign degrees must be evaluated for U.S. equivalency.
- No work experience beyond the doctorate is required for appointment at this level; however, some candidates may have had one or more years of postdoctoral research and training
- Hands-on experience of protein-small molecule crystallography and structure-based virtual screening
- Highly skilled in crystallization of protein-small molecule complexes and high-resolution X-ray structure determination.
- Expertise in biochemical and biophysical assays to characterize protein-small molecule binding interactions.
- Should have theoretical and practical knowledge in the following areas: structure-based methods involving structure-based virtual screening, molecular docking, molecular dynamics simulations etc.
- Must be able to obtain and maintain a security clearance
Candidates with these desired skills will be given preferential consideration:
- Industrial/post-doctoral experience in structure-based drug design or computational chemistry.
- Experience in crystallization of membrane proteins.
- Excellent interpersonal skills with ability to communicate and interact well with colleagues at all levels.
- Highly organized with excellent analytical, documentation and multi-tasking skills.
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