Electron Microscopist/Structural Biologist (NCI)
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR). The dedicated units provide electron microscopy, protein characterization, protein expression, optical microscopy and genetics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR). CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.
KEY ROLES/RESPONSIBILITIES- THIS POSITION IS CONTINGENT UPON FUNDING APPROVAL
- Develop technologies for application on emerging electron microscopy platforms.
- Operate and optimize performance of TEM microscopes, specifically Titan Krios and Talos Artctica for high-resolution data collection in single particle studies as well as cryo-electron tomography.
- Assist with maintenance for the Titan Krios and the Talos Arctica as well as associated instruments.
- Interact closely with and transfer newly developed technical capabilities to CCR Center for Molecular Microscopy (CMM) and CCR collaborators
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
- Possession of a Doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation in Biological Sciences, Structural Biology, or related discipline. Foreign degrees must be evaluated for U.S. equivalency
- In addition to educational requirements, a minimum of eight (8) years of post-graduate experience including five (5) years of independent, competent, and innovative research with Cryo-EM, Cryo-electron tomography, and high resolution single-particle analysis. Three (3) or more years of managerial experience is required.
- Must be detail-oriented and able to manage multiple projects simultaneously
- Able to prepare detailed, concise technical reports
- Strong laboratory skills
- Must be able to obtain and maintain a security clearance
Candidates with these desired skills will be given preferential consideration:
- Experience with negative stain and other specimen preparation techniques for EM
- Experience developing new EM technologies and applications.
- Experience with the microED technology is a plus.
- Use of TEM microscopes, Titan Krios, Talos Arctica, T20.
- Manage sample preparation for cryo-EM studies as well as for negative stain screening.
- Maintenance of TEM microscopes.
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