Scientist (NCI)

Job Number:
Job Category:
Scientist / Research & Development
Day Job
Potential for Teleworking:
Clearance Level Must Currently Possess:
Clearance Level Must Be Able to Obtain:
Public Trust


The Clinical Pharmacodynamic Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the National Cancer Institute (NCI). The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. PADIS facilitates mechanistic and performance analysis of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques that are too high-risk for industry or academia to pursue.


The Scientist will:

  • Design, perform, analyze and present in vitro experiments to test pharmacodynamic marker responses to novel anti-cancer therapeutics in multiple formats, but particularly in multiplex immunofluorescence analysis of tissue based assays
  • Generate materials and data necessary to support the primary experimental objectives of the program
  • Support development and implementation of multiplex immunofluorescence assays in support of clinical studies and initiatives
  • Design experiments and strategies to test and confirm putative mechanism of action of clinical trial candidate compounds
  • Data analysis and reporting of results from clinical specimen biopsies to the NCI



To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a Doctoral degree from an accredited university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • No experience beyond the doctorate is required
  • Demonstration of specific training in cancer biology or drug screening strategies is required
  • Experience in the design and validation of multiplexed immunofluorescence assays and the ability to work across testing platforms during the assay development process
  • Experience with quantitative image analysis software (Definiens)
  • Experience with fluorescence widefield and confocal microscopy
  • Identification and validation of novel biomarkers
  • Design of cell-based assays to test mechanism of action of candidate compounds
  • Ability to master novel technologies and instrumentation in response to changes in project priorities or breakthrough technological innovations; hands-on instrumentation work is required for this position
  • Ability to communicate with program lead researchers in a demanding scientific environment through preparation of formal reports is essential
  • Ability to maintain precise records
  • Must be able to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Experience in elucidating mechanism of action of DNA damaging agents and drugs targeted to DNA repair, cell cycle control and apoptosis
  • A record of publication in the refereed scientific literature
  • Completion of related post-doctoral research and/or training

Expected Competencies:

  • Pharmacology; cancer biology; high content image analysis; confocal microscopy

Leidos Overview:
Leidos is a global science and technology solutions leader working to solve the world’s toughest challenges in the defense, intelligence, homeland security, civil, and health markets. The company’s 33,000 employees support vital missions for government and commercial customers. Headquartered in Reston, Virginia, Leidos reported pro forma annual revenues of approximately $10 billion for the fiscal year ended January 1, 2016 after giving effect to the recently completed combination of Leidos with Lockheed Martin's Information Systems & Global Solutions business (IS&GS). For more information, visit www.Leidos.com. The company’s diverse employees support vital missions for government and commercial customers. Qualified women, minorities, individuals with disabilities and protected veterans are encouraged to apply. Leidos will consider qualified applicants with criminal histories for employment in accordance with relevant Laws. Leidos is an Equal Opportunity Employer.
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